David Celentano

Research and Professional Interests

David Celentano, ScD '77, MHS '75, is Professor and Charles Armstrong Chair of the Department of Epidemiology, with joint appointments in International Health, Health, Society and Behavior and Medicine (School of Medicine). His research integrates behavioral science theory and research with epidemiology, in the study of behavioral and social epidemiology. While originally trained in a chronic disease paradigm (alcoholism and cancer control), he began his research in HIV/AIDS and STDs in the early 1980s. He has worked on some of the major cohort studies (ALIVE, MACS) in HIV epidemiology, as well as conducted intervention research in the USA for heterosexual men and women, injection drug users, and young men who have sex with men.

He turned to international research in 1990, when he began a long-term collaboration with Chiang Mai University in northern Thailand. He has worked on and directed numerous HIV/AIDS and STD epidemiological investigations and preventive interventions. He and his collaborators have demonstrated that a behavioral intervention with young military conscripts lead to a 7-fold reduction in incident STDs and halved the HIV incidence rate. In addition, the role of STDs and alcohol use on HIV acquisition has been shown. More recently, his group has conducted a prospective study of hormonal contraception in relation to HIV seroconversion, a study with significant family planning policy and health implications. Today, he is the Principal Investigator of four NIH-supported studies in Thailand, focusing on interventions to influence the association between opiate use, methamphetamine use, and other drugs on HIV. The focus of these interventions is to harness indigenous peer networks for risk reduction. Other work addresses the use of antiretrovirals and opioid substitution therapy as HIV prevention strategies.

Selected Publications:

  • Lucas, Gregory M., Alicia Young, Deborah Donnell, Paul Richardson, Apinun Aramrattana, Yiming Shao, Yuhua Ruan et al. "Hepatotoxicity in a 52-week randomized trial of short-term versus long-term treatment with buprenorphine/naloxone in HIV-negative injection opioid users in China and Thailand." Drug and alcohol dependence 142 (2014): 139-145. http://www.sciencedirect.com/science/article/pii/S0376871614009211
  • Safren, Steven A., Katie B. Biello, Laura Smeaton, Matthew J. Mimiaga, Ann Walawander, Javier R. Lama, Aadia Rana et al. "Psychosocial Predictors of Non-Adherence and Treatment Failure in a Large Scale Multi-National Trial of Antiretroviral Therapy for HIV: Data from the ACTG A5175/PEARLS Trial." PloS one 9, no. 8 (2014): e104178. http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0104178#pone-0104178-g001
  • Tomori, Cecilia, Kathryn Risher, Rupali J. Limaye, Lynn M. Van Lith, Susannah Gibbs, Marina Smelyanskaya, and David D. Celentano. "A role for health communication in the continuum of HIV care, treatment, and prevention." JAIDS Journal of Acquired Immune Deficiency Syndromes 66 (2014): S306-S310.  http://journals.lww.com/jaids/Abstract/2014/08151/A_Role_for_Health_Communication_in_the_Continuum.10.aspx
  • Cohen, Myron S., Ying Q. Chen, Marybeth McCauley, Theresa Gamble, Mina C. Hosseinipour, Nagalingeswaran Kumarasamy, James G. Hakim et al. "Prevention of HIV-1 infection with early antiretroviral therapy." New England journal of medicine 365, no. 6 (2011): 493-505. http://www.nejm.org/doi/full/10.1056/nejmoa1105243

Regional Experience:

South Arica: Republic of South Africa; Malawi East Africa: United Republic of Tanzania South Asia: India; Thailand; Vietnam; China

Research Tools:

Statistical Analysis, Social Science

Themes Categories:

Water and Health
Water in the Environment

People Categories:

Faculty

Keywords:

David Celentano, epidemiology, international health